I prefer east ave but its mostly a 18 (pretending to be 21) to 26 crowd. SoHo is a nice club but its usually packed, Daisy Dukes is a great country bar with good looking girls, and you can walk across the street to Bayu Billys.
If you want to get away from that type of crowd, you can check out some places on Monroe Ave too which tend to be more like Elmwood in Buffalo.