Not quite. The Desert Eagle can be fitted in a .45, .44 mag, and I believe a .45 winchester mag. The .500 S&W is a MUCh morepowerful gun. It is a fucking cannon. The .454 Causul (sp) is only .004" smaller than the .45, but it is like getting hit with a cinderblock vs a brick…and the .500 S&W would be like a 100lb boulder lol.