Are you going alone? If not then go check out Carmines on Broadway in times square, GREAT FOOD… beware, if you order something it comes on a turkey platter!
Also, if you want an extremely good true brick over pizza… hit up Lombardis, its in little Italy. Featured on the food channel. Best pizza I ever had.
32 Spring St
New York, NY 10012
(212) 941-7994
Cross Street: Corner of Spring and Mott Street (the number 6 subway line is only a block away)
My uncle lives in Manhattan so I go up there all the time.