I’ve never seen the show either but right under the #'s in the link there is another link to ‘reference’ which explains the significance. Also a simple google search of ‘mega millions’ a click on the news tab and it’s the first story you see along with similar stories from different news outlets.
EX: http://www.people.com/people/article/0,,20455051,00.html
The Numbers | Lostpedia | Fandom