It depends what you are looking for.
Do you want a house? If yes then what do you want to spend.
Getting a new house in the wheatfield developments is really nice, but thats a hike if you have to drive into the city every day. Not too bad compared to other cities, but its a hike.
I have an apt in west seneca. I really like the town, lots of nice homes, proud people, no crime, nothing.
I pay 435 a month for a huge 2br upper with a full basement and attic. Its a good cheap deal for me until I buy a house in another state.
I have a driveway that will hold 10 cars no problem, I can have people over and not worry about them parking in the street.
My buddy on the other hand lives in Allentown on college street. He loves it, he pays a fortune for rent, but its walking distance to the allentown bars, and even chippewa if you like a bit of a walk.
His car was broken into 2 times, and recently a city plow hammered the rear of his car, but he still loves it.
Depends what you want.
Some areas of north buffalo are really nice.
Areas to avoid would be the east side entirely, most areas on the west side, certain areas of cheektowaga, some parts of downtown.