If you can spend that much then that would be a good way to go. I personally think that there are some decent heads for much less than the AFRs but they are top notch if you want to pay for them. The only thing to decide on is the cam then. Some people act like others are bashing the Trex or other “big” cams. That isn’t the case at all (at least from me)…it just depends on what YOU want. All I’m saying is don’t make your car the way you think others want it to be. Take some time and decide what you want it to be like. Once you know exactly what your goals are THEN people can tell you how to best make it that way. You should just also take the time to know the possible down sides to every option. The drivability of a Trex type cam certainly is a possible downside depending on what you want. Yes good tuning can make a huge difference but also, everyone has different thresholds to what annoys them when they have to drive it every day. Could be perfect for some and others would hate it. Also with a cam that big and such steep ramps, there is definitely more possible maintenance down the road with the valve train. To a lot of people it’s a perfectly worthwhile trade off…some not.
Btw I also have a C5 and will be doing heads/cam myself. It is my personal preference to not go to a cam that requires revving out to 7000 rpm. I don’t want to worry about changing my springs for a long time. I don’t want it to sound or act like a track car. I don’t think it’s wrong to go “big” if that’s what you want but it isn’t what I want. I’ll be shooting for 425-450 rwhp and that will be good enough for me. I don’t think I’ll be going any bigger than 230 on the duration of my cam and probably just under .600 lift to keep the ramp rates down some. I my engine to peak around 6000 rpm instead of 7000 which means I’ll need the intake valve closing at around 39-40* ABDC. You should also keep your dynamic compression up around 8.5-8.7 on 93 octane and that will help you with your lower end torque if you do go big on the cam. If I do decide I want more down the road then I’ll buy a charger for it and it’ll still drive almost stock till you’re on it. 425-450 rwhp will be far from having bragging rights around here (or anywhere else) but that’s not what I’m interested in anyway and with a good matched setup and good tires that hook it should run 11’s no problem and that’ll make me plenty happy 
Also if you plan to make some good power and then put some tires on that will hook up, you’re going to break some shit. The first thing I’m doing (before any other mods) probably when I put the AR headers on is pull the rear end, differential, torque tube and put a better clutch in, a hardened left hand output shaft, and a support brace on the rear end. There are guys with stock power in the C5’s that have dropped the hammer at only 2500 rpm at the track with good tires and destroyed their whole rear driveline. I don’t want to deal with that. It would be nice to make a ton of power but not if it snaps and you have to call a flat bed and then spend $5000 to make it hold up.
It would be pretty boring if everyone did the same things anyway. Good luck with what ever you decide to do with it. :beer2: