Maybe yes maybe no. I really couldn’t make an inteligent guess one way or the other. I have seen a couple trucks that present with an intermitent p0300. Almost impossible to replicate, but once you tear into the engine you find issues with the lifters controled by the VLOM (variable lifter oil manifold) are collapsed and the cam is oftened damaged. Even if it doesn’t look bad you just replace it since cam and lifters wear into eachother and create unique paterns.
Far as the code thing. If the lifters get bad enough they create a vibration that is transmitted through the block that the knock sensors read as a missfire.