N2O will cause more damage than boost will with the stock bottom end. On the street, you don’t always need the boost either. These motors make plenty of torque, so you won’t be into the boost often. On the street, you can run much lower boost 5-10 psi & that motor will last forever. Syclones/Typhoons when stock made max 14.7 psi on a junk 4.3 bottom end and they held up just fine.
Parish’s 6.0 had a stock bottom end (originally - I don’t know if that was true in the end) & was making waaay more than 450 horses.
Donovans just don’t grow on trees, you know.